Fullmetal Alchemist: Brotherhood
A definitive list of things wrong with Fullmetal Alchemist: Brotherhood: the second half doesn't focus on the Elric brothers enough, the opening episodes move too quickly for newcomers, some of the episode cliffhangers feel forced, the cities are unimaginatively named. With those out of the way, all that's left to say is that this is probably one of the finest, most unspeakably brilliant series to have ever been produced. Flaws are present but they are insignificant in comparison to the wealth of overriding positives - every element is sublimely constructed whether that's the story, characters or animation and for once a series has the budget and creative clout to thoroughly trounce all but the most high-profile productions. It may not be perfect, but it is the closest that any series or movie has yet reached and it transcends its media to achieve something extraordinarily special.
Edward and Alphonse Elric are alchemists, gifted from a young age they are the youngest to have ever joined the state military. Their past however is far from blessed, the death of their mother and their subsequent handling was not without its consequences, for one Ed lost both an arm and a leg, now replaced with prosthetic "auto-mail". Al on the other hand lost his entire body, he is now soul-bound to a suit of armour - able to move and talk but not eat, sleep or feel the touch of another. Together they are on a quest to regain their bodies, but dark forces are stirring and their foes - both human and alchemy borne - are many. Their friends are equally numerous though, and with the help of people like Mustang, the flame alchemist, their old teacher Izumi and their childhood friend Winry, they could well triumph over such world-encompassing adversity.